DESCRIPTION

Gapdon DSR also prescribed to the patients of peptic ulcer and who take certain medicines for Parkinson’s disease. The medicine tightens the muscles near the entrance of the stomach and relaxes the ones present at the exit. Gapdon DSR is Manufactured/Marketed by Gaphel Pharma.

The action of Gapdon DSR medication helps to speed up the passing of the food that you intake - from your stomach to your intestine, reducing the feeling of nausea and sickness, also preventing vomiting.

This medicine also works by blocking or reducing the stimulation in the ‘vomiting centre’ of your brain, which will eventually reduce the feeling of nausea and vomiting. The possible side effects of taking this medication can be headache, migraine, dryness of the mouth or breast pain.

Dosage of Gapdon DSR Capsule

Overdose

• Symptoms of overdose include confusion, anxiety, fits, altered consciousness, sleepiness, etc.
• If you think you have taken too much of this medicine, contact your doctor immediately or visit the nearest hospital Missed a Dose
• If you missed any dose of Gapdon-DSR capsule take it as soon as you remember
• If it's time for your next dose, then skip the missed dose and continue with your regular dose schedule
• Do not take a double dose of medicine to compensate for the missed one

INDICATIONS:

● GERD
● Acid Peptic Disorder
● Reflux Oesophagitis
● Gastric Ulser
● Dyspepsia
● Duodenal Ulcer Syndrome
● Sour Stomach
● Bloating

HOW TO USE GAPDON DSR CAPSULE

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Gapdon DSR Capsule is to be taken empty stomach.
Take it preferably 30 minutes before food.

HOW GAPDON DSR WORKS

Gapdon DSR Capsule is a combination of two medicines: Domperidone and Rabeprazole. Domperidone is a prokinetic which works on the upper digestive tract to increase the movement of the stomach and intestines, allowing the food to move more easily through the stomach. Rabeprazole is a proton pump inhibitor (PPI) which works by reducing the amount of acid in the stomach which helps in the relief of acid-related indigestion and heartburn.

Mechanism of Action of Rabeprazole

Rabeprazole sodium is a proton pump inhibitor. It is a prodrug. After administration it diffuses in to the parietal cell of the stomach and accumulates in the secretory canaliculi. In the acidic medium Rabeprazole is converted to sulfenamide. This sulfenamide covalently interacts with sulfhydryl (SH) group in the proton pump (H+ K+ATPase) and inhibits the exchange of extracellular K+ for intracellular H+ ion. Rabeprazole sodium irreversibly inhibits proton pumps activity and decreases gastric acid secretion. Rabeprazole produces fastest acid suppression and helps in mucin synthesis.

Mechanism of Action of Domperidone

Domperidone is a potent dopamine receptor antagonist. It acts centrally and blocks the Dopamine receptor in the Chemoreceptor trigger zone and produces Antiemetic effect.
Domperidone acts peripherally in the gastrointestinal system and increases oesophageal peristalsis, oesophageal sphincter pressure and gastric motility. These all facilitates gastric emptying. Domperidone is used in migraine to relieve nausea and vomiting. Anaesthetic adjuncts: It is used preoperatively in order to reduce the post operative vomiting

GAPDON DSR CAPSULE RELATED WARNINGS

Alcohol
UNSAFE
GAPDON DSR is unsafe to consume alcohol with $name Taking a large amount of alcohol can increase acidity and cause acid reflux in the food pipe causing heartburn. This would decrease the effect of this drug and can aggravate your underlying condition.

Pregnancy
CONSULT YOUR DOCTOR
GAPDON DSR Capsule may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Lactation
CONSULT YOUR DOCTOR
GAPDON DSR Capsule is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving
UNSAFE
GAPDON DSR Capsule may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney
CAUTION
GAPDON DSR Capsule should be used with caution in patients with kidney disease. Dose adjustment of Gapdon DSR Capsule may be needed. Please consult your doctor.

Liver
CAUTION
GAPDON DSR Capsule should be used with caution in patients with liver disease. Dose adjustment of GAPDON DSR Capsule may be needed. Please consult your doctor.

Use of GAPDON DSR Capsule is not recommended in patients with moderate and severe liver disease. ________________________________________

You may feel a burning in the chest or throat called heartburn. Sometimes, you can taste stomach fluid in the back of the mouth. If you have these symptoms more than twice a week, you may have GERD. You can also have GERD without having heartburn. Your symptoms could include a dry cough, asthma symptoms, or trouble swallowing. Anyone, including infants and children, can have GERD. If not treated, it can lead to more serious health problems. In some cases, you might need medicines or surgery. However, many people can improve their symptoms by…..

• Avoiding alcohol and spicy, fatty or acidic foods that trigger heartburn

• Avoiding alcohol and spicy, fatty or acidic foods that trigger heartburn

• Eating smaller meals

• Not eating close to bedtime

• Losing weight if needed

• Wearing loose-fitting clothes